Cellular regeneration for lasting skin renewal.
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Polynucleotides (PDRN, polydeoxyribonucleotide) are advanced bio-stimulating injectables that work at the cellular level to repair and regenerate skin. Derived from salmon DNA, they stimulate fibroblasts to produce new collagen and elastin, while improving skin hydration and reducing inflammation. This treatment addresses ageing at its source.
Stimulates cellular repair and regeneration. Dramatically improves under-eye area. Strengthens skin barrier and elasticity. Reduces fine lines and skin laxity. Long-lasting results with cumulative improvement. Safe and natural mechanism. Works beautifully with all other treatments.
Anyone experiencing skin ageing, sun damage, or poor elasticity. Ideal for under-eye concerns such as dark circles, hollowness, and crepey texture. Perfect for those wanting deep regeneration. Suitable for mature skin and those seeking preventative anti-ageing. Works on all skin types and tones.
Minimal preparation needed. After treatment: avoid touching treated areas for 24 hours, skip strenuous exercise and saunas for 48 hours, avoid facials and massage for a week, use gentle skincare, and apply SPF 50+ daily. Results develop progressively over 12 weeks.
Subtle improvement visible at 2 weeks. Significant improvement at 4–6 weeks. Peak results at 12 weeks as cellular regeneration continues. Results last 12–18 months. Effects continue improving during and after the treatment period. Many patients do courses of 2–4 treatments for optimal results.
Polynucleotides are derived from highly purified salmon DNA. The extraction process removes all proteins, leaving only the DNA fragments that have been shown to stimulate the skin's own repair mechanisms. The product is extensively tested and CE-marked for safety.
While both are injectable treatments that improve skin quality, they work differently. Profhilo uses hyaluronic acid to hydrate and stimulate collagen indirectly. PDRN works at the cellular level, activating biological repair pathways to regenerate skin from within. They can be used together for a comprehensive approach.
Most patients find polynucleotide injections very comfortable. A topical numbing cream can be applied beforehand to minimise any discomfort. You may experience mild redness or swelling at the injection sites for a few hours after treatment, which typically resolves quickly.
A course of 2–4 sessions spaced 2–4 weeks apart is typically recommended for optimal results. Dr. Patel will advise on the best protocol for your skin concerns during your consultation. Maintenance treatments every 12–18 months help sustain the results.
Polynucleotides are one of the most effective treatments for the under-eye area, addressing dark circles, hollowness, fine lines, and crepey texture. The regenerative properties of PDRN make it especially well-suited to the delicate periorbital area, where Dr. Patel has extensive experience.
Book a personalised consultation with Dr. Nikita Patel to discuss your aesthetic goals and create your bespoke treatment plan.
Consultation Includes